So..Imagine getting all the benefits of exercise, without having to actually move!
Michigan Medicine researchers studying a class of naturally occurring protein called Sestrin have found that it can mimic many of exercise’s beneficial effects in flies and mice. The findings—which were published in Nature Communications this week—could eventually help scientists combat muscle wasting due to aging and other causes.
Taking advantage of Drosophilaflies’ normal instinct to climb up and out of a test tube, their collaborators developed a type of fly treadmill. Using it, the team trained the flies for three weeks and compared the running and flying ability of normal flies with that of flies bred to lack the ability to make Sestrin. “Flies can usually run around four to six hours at this point and the normal flies’ abilities improved over that period,” says Lee. “The flies without Sestrin did not improve with exercise.”
Could Sestrin supplements be on the horizon?
Not quite YET, says Lee. “Sestrins are not small molecules, but we are working to find small molecule modulators of Sestrin.”
Additionally, adds Kim, scientists still don’t know how exercise produces Sestrin in the body. “This is very critical for future study and could lead to a treatment for people who cannot exercise.”
(photo Getty Images)